DSGN: Design Therapeutics, Inc. insider trading, 5% holders and institutional ownership

From public SEC filings: open-market insider purchases and sales (Form 4, last 180 days), holders of 5% or more (Schedules 13D and 13G) and institutional ownership (Form 13F). Insider and 5% data delayed 48 hours.

Insider trading

0 open-market buys totaling - and 0 sales totaling - in the last 180 days.

Activist and 5% holders

FiledWhatHolderStakeChangeFiling
2026-08-14Fell below 5%Point72 Asset Management, L.P.3.80%SEC
2026-08-14New 13G stakeSirenia Capital Management LP9.50%SEC

Institutional ownership (Q2 2026)

136 institutions reported holding $618.22M of Design Therapeutics, Inc. on Form 13F (125 the quarter before). 27 opened a new position and 16 sold out. Shares held by institutions: +14%.

Largest holdersSharesValue
SR One Capital Management, LP6,526,476$94.44M
Logos Global Management LP3,000,000$43.41M
BAKER BROS. ADVISORS LP2,678,430$38.76M
Driehaus Capital Management LLC2,661,115$38.51M
BlackRock, Inc.2,660,024$38.49M
Point72 Asset Management, L.P.2,366,453$34.24M
Trails Edge Capital Partners, LP2,001,282$28.96M
Frazier Life Sciences Management, L.P.1,809,854$26.19M
Vivo Capital, LLC1,612,903$23.34M
VANGUARD CAPITAL MANAGEMENT LLC1,571,022$22.73M

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